4AED

Crystal structure of Human enterovirus 71

4AED の概要

• エントリーDOI: 10.2210/pdb4aed/pdb
• 分子名称: VP1, VP2, VP3, ... (6 entities in total)
• 機能のキーワード: virus, picornavirus, capsid, pathogen
• 由来する生物種: HUMAN ENTEROVIRUS 71; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95002.17

構造登録者

Plevka, P.,Perera, R.,Kuhn, R.J.,Rossmann, M.G. (登録日: 2012-01-09, 公開日: 2012-04-25, 最終更新日: 2023-12-20)

主引用文献

Plevka, P.,Perera, R.,Cardosa, J.,Kuhn, R.J.,Rossmann, M.G.
Crystal Structure of Human Enterovirus 71.
Science, 336:1274-, 2012

PubMed Abstract: Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

PubMed: 22383808
DOI: 10.1126/SCIENCE.1218713

実験手法

X-RAY DIFFRACTION (3.8 Å)