4ACJ

Crystal structure of the TLDC domain of Oxidation resistance protein 2 from zebrafish

Summary for 4ACJ

• Entry DOI: 10.2210/pdb4acj/pdb
• Descriptor: WU\:FB25H12 PROTEIN, (2 entities in total)
• Functional Keywords: immune system
• Biological source: DANIO RERIO (ZEBRAFISH)
• Total number of polymer chains: 1
• Total formula weight: 18900.16

Authors

Blaise, M.,B Alsarraf, H.M.A.,Wong, J.E.M.M.,Midtgaard, S.R.,Laroche, F.,Schack, L.,Spaink, H.,Stougaard, J.,Thirup, S. (deposition date: 2011-12-15, release date: 2012-02-08, Last modification date: 2024-05-08)

Primary citation

Blaise, M.,Alsarraf, H.M.,Wong, J.E.,Midtgaard, S.R.,Laroche, F.,Schack, L.,Spaink, H.,Stougaard, J.,Thirup, S.
Crystal Structure of the Tldc Domain of Oxidation Resistance Protein 2 from Zebrafish.
Proteins, 80:1694-, 2012

PubMed Abstract: The oxidation resistance proteins (OXR) help to protect eukaryotes from reactive oxygen species. The sole C-terminal domain of the OXR, named TLDc is sufficient to perform this function. However, the mechanism by which oxidation resistance occurs is poorly understood. We present here the crystal structure of the TLDc domain of the oxidation resistance protein 2 from zebrafish. The structure was determined by X-ray crystallography to atomic resolution (0.97Å) and adopts an overall globular shape. Two antiparallel β-sheets form a central β-sandwich, surrounded by two helices and two one-turn helices. The fold shares low structural similarity to known structures.

PubMed: 22434723
DOI: 10.1002/PROT.24050

Experimental method

X-RAY DIFFRACTION (0.97 Å)