4ACJ

Crystal structure of the TLDC domain of Oxidation resistance protein 2 from zebrafish

4ACJ の概要

• エントリーDOI: 10.2210/pdb4acj/pdb
• 分子名称: WU\:FB25H12 PROTEIN, (2 entities in total)
• 機能のキーワード: immune system
• 由来する生物種: DANIO RERIO (ZEBRAFISH)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18900.16

構造登録者

Blaise, M.,B Alsarraf, H.M.A.,Wong, J.E.M.M.,Midtgaard, S.R.,Laroche, F.,Schack, L.,Spaink, H.,Stougaard, J.,Thirup, S. (登録日: 2011-12-15, 公開日: 2012-02-08, 最終更新日: 2024-05-08)

主引用文献

Blaise, M.,Alsarraf, H.M.,Wong, J.E.,Midtgaard, S.R.,Laroche, F.,Schack, L.,Spaink, H.,Stougaard, J.,Thirup, S.
Crystal Structure of the Tldc Domain of Oxidation Resistance Protein 2 from Zebrafish.
Proteins, 80:1694-, 2012

PubMed Abstract: The oxidation resistance proteins (OXR) help to protect eukaryotes from reactive oxygen species. The sole C-terminal domain of the OXR, named TLDc is sufficient to perform this function. However, the mechanism by which oxidation resistance occurs is poorly understood. We present here the crystal structure of the TLDc domain of the oxidation resistance protein 2 from zebrafish. The structure was determined by X-ray crystallography to atomic resolution (0.97Å) and adopts an overall globular shape. Two antiparallel β-sheets form a central β-sandwich, surrounded by two helices and two one-turn helices. The fold shares low structural similarity to known structures.

PubMed: 22434723
DOI: 10.1002/PROT.24050

実験手法

X-RAY DIFFRACTION (0.97 Å)