4ACF

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.

Summary for 4ACF

Entry DOI	10.2210/pdb4acf/pdb
Related	1HTO 1HTQ 2BVC 2WGS 2WHI 3ZXR 3ZXV
Descriptor	GLUTAMINE SYNTHETASE 1, {4-[6-BROMO-3-(BUTYLAMINO)IMIDAZO[1,2-A]PYRIDIN-2-YL]PHENOXY}ACETIC ACID, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	ligase, nucleotide-binding, synthetase, tri-substituted imidazole, taut state, rv2220, mt2278, glna1
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	6
Total formula weight	332945.18
Authors	Nilsson, M.T.,Mowbray, S.L. (deposition date: 2011-12-15, release date: 2012-10-24, Last modification date: 2023-12-20)
Primary citation	Nordqvist, A.,Nilsson, M.T.,Lagerlund, O.,Muthas, D.,Gising, J.,Yahiaoui, S.,Odell, L.R.,Srinivasa, B.R.,Larhed, M.,Mowbray, S.L.,Karlen, A. Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors Medchemcomm, 3:620-, 2012 Cited by DOI: 10.1039/C2MD00310D PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation