4A25

X-ray structure Dps from Kineococcus radiotolerans in complex with Mn (II) ions.

Summary for 4A25

• Entry DOI: 10.2210/pdb4a25/pdb
• Descriptor: FERRITIN DPS FAMILY PROTEIN, MANGANESE (II) ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: metal binding protein, detoxification process
• Biological source: KINEOCOCCUS RADIOTOLERANS
• Total number of polymer chains: 4
• Total formula weight: 74840.71

Authors

Ilari, A.,Fiorillo, A.,Ardini, M.,Stefanini, S.,Chiancone, E. (deposition date: 2011-09-22, release date: 2012-10-03, Last modification date: 2023-12-20)

Primary citation

Ardini, M.,Fiorillo, A.,Fittipaldi, M.,Stefanini, S.,Gatteschi, D.,Llari, A.,Chiancone, E.
Kineococcus Radiotolerans Dps Forms a Heteronuclear Mn-Fe Ferroxidase Center that May Explain the Mn-Dependent Protection Against Oxidative Stress.
Biochim.Biophys.Acta, 1830:3745-, 2013

PubMed Abstract: The ferroxidase center of DNA-binding protein from starved cells (Dps) is a major player in the iron oxidation/detoxification process that leads to a decreased reactive oxygen species production. The possible Mn(II) participation in this process has been studied in Dps from Kineococcus radiotolerans, a radiation-resistant bacterium with a high cytosolic Mn/Fe ratio and a high capacity to survive ionizing and stress conditions.

PubMed: 23396000
DOI: 10.1016/J.BBAGEN.2013.02.003

Experimental method

X-RAY DIFFRACTION (2 Å)