4A14
HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
Summary for 4A14
| Entry DOI | 10.2210/pdb4a14/pdb |
| Related | 2XT3 |
| Descriptor | KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | motor protein, kinesin, motor domain |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cell projection, cilium: Q2M1P5 |
| Total number of polymer chains | 1 |
| Total formula weight | 37897.85 |
| Authors | Klejnot, M.,Kozielski, F. (deposition date: 2011-09-14, release date: 2012-01-25, Last modification date: 2023-12-20) |
| Primary citation | Klejnot, M.,Kozielski, F. Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling. Acta Crystallogr.,Sect.D, 68:154-, 2012 Cited by PubMed Abstract: Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melanogaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance. PubMed: 22281744DOI: 10.1107/S0907444911053042 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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