4A14

HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING

4A14 の概要

• エントリーDOI: 10.2210/pdb4a14/pdb
• 関連するPDBエントリー: 2XT3
• 分子名称: KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: motor protein, kinesin, motor domain
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell projection, cilium: Q2M1P5
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37897.85

構造登録者

Klejnot, M.,Kozielski, F. (登録日: 2011-09-14, 公開日: 2012-01-25, 最終更新日: 2023-12-20)

主引用文献

Klejnot, M.,Kozielski, F.
Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68:154-, 2012

PubMed Abstract: Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melanogaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance.

PubMed: 22281744
DOI: 10.1107/S0907444911053042

実験手法

X-RAY DIFFRACTION (1.6 Å)