4A0E

Crystal structure of the cytoplasmic N-terminal domain of Yersinia pestis YscD

4A0E の概要

• エントリーDOI: 10.2210/pdb4a0e/pdb
• 分子名称: TYPE III SECRETION PROTEIN (2 entities in total)
• 機能のキーワード: transport protein, sad phasing, type iii secretion system
• 由来する生物種: YERSINIA PESTIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26966.83

構造登録者

Lountos, G.T.,Tropea, J.E.,Waugh, D.S. (登録日: 2011-09-08, 公開日: 2012-02-29, 最終更新日: 2024-05-08)

主引用文献

Lountos, G.T.,Tropea, J.E.,Waugh, D.S.
Structure of the Cytoplasmic Domain of Yersinia Pestis Yscd, an Essential Component of the Type III Secretion System
Acta Crystallogr.,Sect.D, 68:201-, 2012

PubMed Abstract: The Yersinia pestis YscD protein is an essential component of the type III secretion system. YscD consists of an N-terminal cytoplasmic domain (residues 1-121), a transmembrane linker (122-142) and a large periplasmic domain (143-419). Both the cytoplasmic and the periplasmic domains are required for the assembly of the type III secretion system. Here, the structure of the YscD cytoplasmic domain solved by SAD phasing is presented. Although the three-dimensional structure is similar to those of forkhead-associated (FHA) domains, comparison with the structures of canonical FHA domains revealed that the cytoplasmic domain of YscD lacks the conserved residues that are required for binding phosphothreonine and is therefore unlikely to function as a true FHA domain.

PubMed: 22349221
DOI: 10.1107/S0907444911054308

実験手法

X-RAY DIFFRACTION (2.042 Å)