4A0D
Structure of unliganded human PARG catalytic domain
Summary for 4A0D
Entry DOI | 10.2210/pdb4a0d/pdb |
Descriptor | POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Isoform 5: Mitochondrion matrix: Q86W56 |
Total number of polymer chains | 1 |
Total formula weight | 61729.11 |
Authors | Brassington, C.,Ellston, J.,Hassall, G.,Holdgate, G.,McAlister, M.,Overman, R.,Smith, G.,Tucker, J.A.,Watson, M. (deposition date: 2011-09-08, release date: 2012-10-17, Last modification date: 2013-01-16) |
Primary citation | Tucker, J.A.,Bennett, N.,Brassington, C.,Durant, S.T.,Hassall, G.,Holdgate, G.,Mcalister, M.,Nissink, J.W.M.,Truman, C.,Watson, M. Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives. Plos One, 7:50889-, 2012 Cited by PubMed: 23251397DOI: 10.1371/JOURNAL.PONE.0050889 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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