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4A0D

Structure of unliganded human PARG catalytic domain

Summary for 4A0D
Entry DOI10.2210/pdb4a0d/pdb
DescriptorPOLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, ... (5 entities in total)
Functional Keywordshydrolase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Isoform 5: Mitochondrion matrix: Q86W56
Total number of polymer chains1
Total formula weight61729.11
Authors
Brassington, C.,Ellston, J.,Hassall, G.,Holdgate, G.,McAlister, M.,Overman, R.,Smith, G.,Tucker, J.A.,Watson, M. (deposition date: 2011-09-08, release date: 2012-10-17, Last modification date: 2013-01-16)
Primary citationTucker, J.A.,Bennett, N.,Brassington, C.,Durant, S.T.,Hassall, G.,Holdgate, G.,Mcalister, M.,Nissink, J.W.M.,Truman, C.,Watson, M.
Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7:50889-, 2012
Cited by
PubMed: 23251397
DOI: 10.1371/JOURNAL.PONE.0050889
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

217705

数据于2024-03-27公开中

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