484D

SOLUTION STRUCTURE OF HIV-1 REV PEPTIDE-RNA APTAMER COMPLEX

484D の概要

• エントリーDOI: 10.2210/pdb484d/pdb
• 分子名称: RNA APTAMER, BASIC REV PEPTIDE (2 entities in total)
• 機能のキーワード: hiv-1 rev peptide; rna aptamer; bound peptide secondary structure, peptide- binding rna, tertiary architectures, adaptive-binding, rna binding protein-rna complex, rna binding protein/rna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 11145.99

構造登録者

Ye, X.,Gorin, A.A.,Frederick, R.,Hu, W.,Majumdar, A.,Xu, W.,Mclendon, G.,Ellington, A.,Patel, D.J. (登録日: 1999-08-02, 公開日: 1999-10-14, 最終更新日: 2023-12-27)

主引用文献

Ye, X.,Gorin, A.,Frederick, R.,Hu, W.,Majumdar, A.,Xu, W.,McLendon, G.,Ellington, A.,Patel, D.J.
RNA architecture dictates the conformations of a bound peptide.
Chem.Biol., 6:657-669, 1999

PubMed Abstract: The biological function of several viral and bacteriophage proteins, and their arginine-rich subdomains, involves RNA-mediated interactions. It has been shown recently that bound peptides adopt either beta-hairpin or alpha-helical conformations in viral and phage peptide-RNA complexes. We have compared the structures of the arginine-rich peptide domain of HIV-1 Rev bound to two RNA aptamers to determine whether RNA architecture can dictate the conformations of a bound peptide.

PubMed: 10467126
DOI: 10.1016/S1074-5521(99)80117-3

実験手法

SOLUTION NMR