462D

CRYSTAL STRUCTURE OF THE HIV-1 GENOMIC RNA DIMERIZATION INITIATION SITE

462D の概要

• エントリーDOI: 10.2210/pdb462d/pdb
• 分子名称: RNA (5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G) -3'), MAGNESIUM ION (3 entities in total)
• 機能のキーワード: hiv, rna duplex, mismatch, bulges, magnesium binding, rna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14999.38

構造登録者

Ennifar, E.,Yusupov, M.,Walter, P.,Marquet, R.,Ehresmann, C.,Ehresmann, B.,Dumas, P. (登録日: 1999-03-18, 公開日: 1999-12-02, 最終更新日: 2023-12-27)

主引用文献

Ennifar, E.,Yusupov, M.,Walter, P.,Marquet, R.,Ehresmann, B.,Ehresmann, C.,Dumas, P.
The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges.
Structure Fold.Des., 7:1439-1449, 1999

PubMed Abstract: An important step in retroviral replication is dimerization of the genomic RNA prior to encapsidation. Dimerization is initiated by the formation of a transient 'kissing-loop complex' that is thought to be subsequently matured into an extended duplex by the nucleocapsid protein (NCp). Although chemical probing and nuclear magnetic resonance spectroscopy have provided insight into the structure of the kissing-loop structure, no structural information concerning the extended-duplex state is available so far.

PubMed: 10574792
DOI: 10.1016/S0969-2126(00)80033-7

実験手法

X-RAY DIFFRACTION (2.3 Å)