407D

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

Summary for 407D

• Entry DOI: 10.2210/pdb407d/pdb
• Descriptor: DNA (5'-D(*CP*CP*AP*GP*TP*AP*CP*TP*GP*G)-3'), ~{N}-[5-[[5-[[5-[[3-[3-(dimethylamino)propylamino]-3-oxidanylidene-propyl]carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-4-oxidanyl-pyrrol-3-yl]-1-methyl-imidazole-2-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: drugs in the dna minor groove, dna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 7539.60

Authors

Rees, D.C. (deposition date: 1998-06-24, release date: 1998-10-19, Last modification date: 2024-02-28)

• Primary citation: Kielkopf, C.L.,White, S.,Szewczyk, J.W.,Turner, J.M.,Baird, E.E.,Dervan, P.B.,Rees, D.C.; A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA.; Science, 282:111-115, 1998; PubMed: 9756473; DOI: 10.1126/science.282.5386.111

Experimental method

X-RAY DIFFRACTION (2.2 Å)