402D

5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'

402D の概要

• エントリーDOI: 10.2210/pdb402d/pdb
• 分子名称: RNA(5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3') (2 entities in total)
• 機能のキーワード: rna double helix, rna with tandem c-a+ base pair, rna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 5081.19

構造登録者

Jang, S.B.,Hung, L.-W.,Chi, Y.-I.,Holbrook, E.L.,Carter, R.,Holbrook, S.R. (登録日: 1998-06-04, 公開日: 1998-06-16, 最終更新日: 2024-02-28)

主引用文献

Jang, S.B.,Hung, L.W.,Chi, Y.I.,Holbrook, E.L.,Carter, R.J.,Holbrook, S.R.
Structure of an RNA internal loop consisting of tandem C-A+ base pairs.
Biochemistry, 37:11726-11731, 1998

PubMed Abstract: The crystal structure of the RNA octamer 5'-CGC(CA)GCG-3' has been determined from X-ray diffraction data to 2.3 A resolution. In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit. Tandem non-Watson-Crick C-A and A-C base pairs comprise an internal loop in the middle of the duplex, which is incorporated with little distortion of the A-form double helix. From the geometry of the C-A base pairs, it is inferred that the adenosine imino group is protonated and donates a hydrogen bond to the carbonyl group of the cytosine. The wobble geometry of the C-A+ base pairs is very similar to that of the common U-G non-Watson-Crick pair.

PubMed: 9718295
DOI: 10.1021/bi980758j

実験手法

X-RAY DIFFRACTION (2.3 Å)