3ZXP

Structural and Functional Analyses of the Bro1 Domain Protein BROX

3ZXP の概要

• エントリーDOI: 10.2210/pdb3zxp/pdb
• 分子名称: BRO1 DOMAIN-CONTAINING PROTEIN BROX (2 entities in total)
• 機能のキーワード: protein transport
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Membrane; Lipid-anchor (Potential): Q5VW32
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 138223.32

構造登録者

Zhai, Q.,Landesman, M.B.,Sundquist, W.I.,Hill, C.P. (登録日: 2011-08-13, 公開日: 2011-11-16, 最終更新日: 2024-05-08)

主引用文献

Zhai, Q.,Landesman, M.B.,Robinson, H.,Sundquist, W.I.,Hill, C.P.
Structure of the Bro1 Domain Protein Brox and Functional Analyses of the Alix Bro1 Domain in HIV-1 Budding.
Plos One, 6:27466-, 2011

PubMed Abstract: Bro1 domains are elongated, banana-shaped domains that were first identified in the yeast ESCRT pathway protein, Bro1p. Humans express three Bro1 domain-containing proteins: ALIX, BROX, and HD-PTP, which function in association with the ESCRT pathway to help mediate intraluminal vesicle formation at multivesicular bodies, the abscission stage of cytokinesis, and/or enveloped virus budding. Human Bro1 domains share the ability to bind the CHMP4 subset of ESCRT-III proteins, associate with the HIV-1 NC(Gag) protein, and stimulate the budding of viral Gag proteins. The curved Bro1 domain structure has also been proposed to mediate membrane bending. To date, crystal structures have only been available for the related Bro1 domains from the Bro1p and ALIX proteins, and structures of additional family members should therefore aid in the identification of key structural and functional elements.

PubMed: 22162750
DOI: 10.1371/JOURNAL.PONE.0027466

実験手法

X-RAY DIFFRACTION (2.495 Å)