3ZSX

Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design

3ZSX の概要

• エントリーDOI: 10.2210/pdb3zsx/pdb
• 関連するPDBエントリー: 1HYV 1HYZ 3ZSO 3ZSQ 3ZSR 3ZSV 3ZSW 3ZSY 3ZSZ 3ZT0 3ZT1 3ZT2 3ZT3 3ZT4
• 分子名称: INTEGRASE, SULFATE ION, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: transferase, aids
• 由来する生物種: HUMAN IMMUNODEFICIENCY VIRUS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38709.47

構造登録者

Peat, T.S.,Newman, J.,Rhodes, D.I.,Vandergraaff, N.,Le, G.,Jones, E.D.,Smith, J.A.,Coates, J.A.V.,Thienthong, N.,Dolezal, O.,Ryan, J.H.,Savage, G.P.,Francis, C.L.,Deadman, J.J. (登録日: 2011-07-01, 公開日: 2012-07-11, 最終更新日: 2012-08-01)

• 主引用文献: Peat, T.S.,Rhodes, D.I.,Vandegraaff, N.,Le, G.,Smith, J.A.,Clark, L.J.,Jones, E.D.,Coates, J.A.V.,Thienthong, N.,Newman, J.,Dolezal, O.,Mulder, R.,Ryan, J.H.,Savage, G.P.,Francis, C.L.,Deadman, J.J.; Small Molecule Inhibitors of the Ledgf Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.; Plos One, 7:40147-, 2012; PubMed: 22808106; DOI: 10.1371/JOURNAL.PONE.0040147

実験手法

X-RAY DIFFRACTION (1.95 Å)