3ZS1

Human Myeloperoxidase inactivated by TX5

3ZS1 の概要

• エントリーDOI: 10.2210/pdb3zs1/pdb
• 関連するPDBエントリー: 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3ZS0
• 分子名称: MYELOPEROXIDASE LIGHT CHAIN, ACETATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• 機能のキーワード: oxidoreductase, enzyme inactivation, inflammation, neutrophil, reactive oxygen species (ros), hypochlorous acid
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Lysosome: P05164 P05164
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 137114.53

構造登録者

Tiden, A.K.,Sjogren, T.,Svensson, M.,Bernlind, A.,Senthilmohan, R.,Auchere, F.,Norman, H.,Markgren, P.O.,Gustavsson, S.,Schmidt, S.,Lundquist, S.,Forbes, L.V.,Magon, N.J.,Jameson, G.N.,Eriksson, H.,Kettle, A.J. (登録日: 2011-06-21, 公開日: 2011-08-31, 最終更新日: 2023-12-20)

• 主引用文献: Tiden, A.K.,Sjogren, T.,Svensson, M.,Bernlind, A.,Senthilmohan, R.,Auchere, F.,Norman, H.,Markgren, P.O.,Gustavsson, S.,Schmidt, S.,Lundquist, S.,Forbes, L.V.,Magon, N.J.,Paton, L.N.,Jameson, G.N.,Eriksson, H.,Kettle, A.J.; 2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.; J.Biol.Chem., 286:37578-, 2011; PubMed: 21880720; DOI: 10.1074/JBC.M111.266981

実験手法

X-RAY DIFFRACTION (2.6 Å)