3ZR9

Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)

Summary for 3ZR9

Entry DOI	10.2210/pdb3zr9/pdb
Descriptor	BETA-LACTAMASE NDM-1, ZINC ION, COBALT (II) ION, ... (6 entities in total)
Functional Keywords	hydrolase
Biological source	KLEBSIELLA PNEUMONIAE
Cellular location	Periplasm (Potential): C7C422
Total number of polymer chains	1
Total formula weight	24814.90
Authors	Green, V.L.,Verma, A.,Owens, R.J.,Phillips, S.E.V.,Carr, S.B. (deposition date: 2011-06-15, release date: 2011-06-29, Last modification date: 2023-12-20)
Primary citation	Green, V.L.,Verma, A.,Owens, R.J.,Phillips, S.E.,Carr, S.B. Structure of New Delhi Metallo-Beta-Lactamase 1 (Ndm-1). Acta Crystallogr.,Sect.F, 67:1160-, 2011 Cited by PubMed Abstract: Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-β-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1. PubMed: 22102018 DOI: 10.1107/S1744309111029654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation