3ZME

Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242

Summary for 3ZME

• Entry DOI: 10.2210/pdb3zme/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION, 2-(4-(4-fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazol-1-yl)-N,N-dimethylethanamine, ... (4 entities in total)
• Functional Keywords: transcription, cell cycle, apoptosis, cancer mutation, protein stabilization
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 49789.16

Authors

Joerger, A.C.,Wilcken, R. (deposition date: 2013-02-07, release date: 2013-05-08, Last modification date: 2019-05-15)

• Primary citation: Liu, X.,Wilcken, R.,Joerger, A.C.,Chuckowree, I.S.,Amin, J.,Spencer, J.,Fersht, A.R.; Small molecule induced reactivation of mutant p53 in cancer cells.; Nucleic Acids Res., 41:6034-6044, 2013; PubMed: 23630318; DOI: 10.1093/nar/gkt305

Experimental method

X-RAY DIFFRACTION (1.35 Å)