3ZM6
CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Summary for 3ZM6
Entry DOI | 10.2210/pdb3zm6/pdb |
Related | 3ZL8 3ZM5 |
Descriptor | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE, N-(6-(4-(2h-tetrazol-5-yl)benzyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide (3 entities in total) |
Functional Keywords | ligase, peptidoglycan synthesis, adp-forming enzyme, cell wall, cell shape, cell cycle, cell divison, nucleotide-binding, atp-binding |
Biological source | STREPTOCOCCUS PNEUMONIAE |
Cellular location | Cytoplasm (By similarity): Q8DNV6 |
Total number of polymer chains | 1 |
Total formula weight | 52289.97 |
Authors | Hrast, M.,Turk, S.,Sosic, I.,Knez, D.,Randall, C.P.,Barreteau, H.,Contreras-Martel, C.,Dessen, A.,ONeill, A.J.,Mengin-Lecreulx, D.,Blanot, D.,Gobec, S. (deposition date: 2013-02-05, release date: 2013-07-03, Last modification date: 2023-12-20) |
Primary citation | Hrast, M.,Turk, S.,Sosic, I.,Knez, D.,Randall, C.P.,Barreteau, H.,Contreras-Martel, C.,Dessen, A.,O'Neill, A.J.,Mengin-Lecreulx, D.,Blanot, D.,Gobec, S. Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf. Eur.J.Med.Chem., 66C:32-, 2013 Cited by PubMed: 23786712DOI: 10.1016/J.EJMECH.2013.05.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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