3ZM6

CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR

3ZM6 の概要

• エントリーDOI: 10.2210/pdb3zm6/pdb
• 関連するPDBエントリー: 3ZL8 3ZM5
• 分子名称: UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE, N-(6-(4-(2h-tetrazol-5-yl)benzyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide (3 entities in total)
• 機能のキーワード: ligase, peptidoglycan synthesis, adp-forming enzyme, cell wall, cell shape, cell cycle, cell divison, nucleotide-binding, atp-binding
• 由来する生物種: STREPTOCOCCUS PNEUMONIAE
• 細胞内の位置: Cytoplasm (By similarity): Q8DNV6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52289.97

構造登録者

Hrast, M.,Turk, S.,Sosic, I.,Knez, D.,Randall, C.P.,Barreteau, H.,Contreras-Martel, C.,Dessen, A.,ONeill, A.J.,Mengin-Lecreulx, D.,Blanot, D.,Gobec, S. (登録日: 2013-02-05, 公開日: 2013-07-03, 最終更新日: 2023-12-20)

• 主引用文献: Hrast, M.,Turk, S.,Sosic, I.,Knez, D.,Randall, C.P.,Barreteau, H.,Contreras-Martel, C.,Dessen, A.,O'Neill, A.J.,Mengin-Lecreulx, D.,Blanot, D.,Gobec, S.; Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.; Eur.J.Med.Chem., 66C:32-, 2013; PubMed: 23786712; DOI: 10.1016/J.EJMECH.2013.05.013

実験手法

X-RAY DIFFRACTION (1.84 Å)