3ZI6

Structure of thermolysin solved by SAD from data collected by Direct Data Collection (DDC) using the GRob robot goniometer

3ZI6 の概要

• エントリーDOI: 10.2210/pdb3zi6/pdb
• 関連するPDBエントリー: 3ZI7
• 分子名称: THERMOLYSIN, VALINE, LYSINE, ... (6 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: BACILLUS THERMOPROTEOLYTICUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34852.37

構造登録者

Bowler, M.W. (登録日: 2013-01-04, 公開日: 2013-05-01, 最終更新日: 2024-05-08)

主引用文献

Ferrer, J.L.,Larive, N.A.,Bowler, M.W.,Nurizzo, D.
Recent Progress in Robot-Based Systems for Crystallography and Their Contribution to Drug Discovery.
Expert Opin.Drug Discov., 8:835-, 2013

PubMed Abstract: X-ray crystallography is the main tool for macromolecular structure solution at atomic resolution. It provides key information for the understanding of protein function, opening opportunities for the modulation of enzymatic mechanisms, and protein-ligand interactions. As a consequence, macromolecular crystallography plays an essential role in drug design, as well as in the a posteriori validation of drug mechanisms.

PubMed: 23656378
DOI: 10.1517/17460441.2013.793666

実験手法

X-RAY DIFFRACTION (2 Å)