3ZGN

Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway

3ZGN の概要

• エントリーDOI: 10.2210/pdb3zgn/pdb
• 関連するPDBエントリー: 3ZGL
• 分子名称: 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, (2E)-3-methyl-4-sulfanylbut-2-en-1-yl trihydrogen diphosphate, IRON/SULFUR CLUSTER, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, mep pathway, inhibitors, 4fe-4s cluster
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74538.63

構造登録者

Borel, F.,Barbier, E.,Kratsutsky, S.,Janthawornpong, K.,Rohmer, M.,Dale Poulter, C.,Ferrer, J.L.,Seemann, M. (登録日: 2012-12-18, 公開日: 2013-01-09, 最終更新日: 2023-12-20)

• 主引用文献: Borel, F.,Barbier, E.,Krasutsky, S.,Janthawornpong, K.,Chaignon, P.,Poulter, C.D.,Ferrer, J.L.,Seemann, M.; Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.; Chembiochem, 18:2137-2144, 2017; PubMed: 28862365; DOI: 10.1002/cbic.201700363

実験手法

X-RAY DIFFRACTION (1.95 Å)