3ZDU
Crystal structure of the human CDKL3 kinase domain
Summary for 3ZDU
Entry DOI | 10.2210/pdb3zdu/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE-LIKE 3, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ZINC ION, ... (6 entities in total) |
Functional Keywords | transferase, phospho-mimetic |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : Q8IVW4 |
Total number of polymer chains | 1 |
Total formula weight | 37988.75 |
Authors | Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Pike, A.C.W.,Quigley, A.,MacKenzie, A.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2012-11-30, release date: 2013-03-20, Last modification date: 2023-12-20) |
Primary citation | Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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