3ZDU

Crystal structure of the human CDKL3 kinase domain

Summary for 3ZDU

DescriptorCYCLIN-DEPENDENT KINASE-LIKE 3, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ZINC ION, ... (6 entities in total)
Functional Keywordstransferase, phospho-mimetic
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm  Q8IVW4
Total number of polymer chains1
Total molecular weight37988.75
Authors
Primary citation
Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Pike, A.C.W.,Quigley, A.,MacKenzie, A.,Carpenter, E.P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.
Crystal Structure of the Human Cdkl3 Kinase Domain
To be Published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.269301.3%4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution