3ZC6
Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine inhibitor
Summary for 3ZC6
Entry DOI | 10.2210/pdb3zc6/pdb |
Descriptor | TYROSINE-PROTEIN KINASE JAK3, N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
Functional Keywords | transferase, scid, severe combined immunodeficiency, stat5, stat6, interleukin-2, common-gamma chain, atp site kinase inhibitor, cancer |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): P52333 |
Total number of polymer chains | 4 |
Total formula weight | 134422.32 |
Authors | Kuglstatter, A.,Jestel, A.,Nagel, S.,Boettcher, J.,Blaesse, M. (deposition date: 2012-11-16, release date: 2013-09-25) |
Primary citation | Lynch, S.M.,Devicente, J.,Hermann, J.C.,Jaime-Figueroa, S.,Jin, S.,Kuglstatter, A.,Li, H.,Lovey, A.,Menke, J.,Niu, L.,Patel, V.,Roy, D.,Soth, M.,Steiner, S.,Tivitmahaisoon, P.,Vu, M.D.,Yee, C. Strategic Use of Conformational Bias and Structure Based Design to Identify Potent Jak3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome. Bioorg.Med.Chem.Lett., 23:2793-, 2013 Cited by PubMed: 23540648DOI: 10.1016/J.BMCL.2013.02.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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