3WXC

Crystal Structure of IMP-1 metallo-beta-lactamase complexed with a 3-aminophtalic acid inhibitor

Summary for 3WXC

Entry DOI	10.2210/pdb3wxc/pdb
Descriptor	Beta-lactamase, ZINC ION, 3-(4-hydroxypiperidin-1-yl)benzene-1,2-dicarboxylic acid, ... (4 entities in total)
Functional Keywords	lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	49862.17
Authors	Saito, J.,Watanabe, T.,Yamada, M. (deposition date: 2014-07-29, release date: 2014-10-15, Last modification date: 2024-04-03)
Primary citation	Hiraiwa, Y.,Saito, J.,Watanabe, T.,Yamada, M.,Morinaka, A.,Fukushima, T.,Kudo, T. X-ray crystallographic analysis of IMP-1 metallo-beta-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors Bioorg.Med.Chem.Lett., 24:4891-4894, 2014 Cited by PubMed: 25246278 DOI: 10.1016/j.bmcl.2014.08.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation