3WNR

Multiple binding modes of benzyl isothiocyanate inhibitor complexed with Macrophage Migration Inhibitory Factor

3WNR の概要

• エントリーDOI: 10.2210/pdb3wnr/pdb
• 関連するPDBエントリー: 3WNS 3WNT 4f2k 4OSF
• 分子名称: Macrophage migration inhibitory factor, N-benzylthioformamide, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: cytokine, tautomerase, isomerae, benzyl isothiocyante, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P14174
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 38495.09

構造登録者

Spencer, E.S.,Dale, E.J.,Gommans, A.L.,Rutledge, M.T.,Gamble, A.B.,Smith, R.A.J.,Wilbanks, S.M.,Hampton, M.B.,Tyndall, J.D.A. (登録日: 2013-12-16, 公開日: 2014-03-05, 最終更新日: 2023-11-08)

• 主引用文献: Spencer, E.S.,Dale, E.J.,Gommans, A.L.,Rutledge, M.T.,Vo, C.T.,Nakatani, Y.,Gamble, A.B.,Smith, R.A.,Wilbanks, S.M.,Hampton, M.B.,Tyndall, J.D.; Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor; Eur.J.Med.Chem., 93:501-510, 2015; PubMed: 25743213; DOI: 10.1016/j.ejmech.2015.02.012

実験手法

X-RAY DIFFRACTION (2.008 Å)