3WL9

HLA-A24 in complex with HIV-1 Nef126-10(8I10F)

3WL9 の概要

• エントリーDOI: 10.2210/pdb3wl9/pdb
• 関連するPDBエントリー: 3WLB
• 分子名称: HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, Protein Nef, ... (4 entities in total)
• 機能のキーワード: hiv-1, nef, hla-a24, mhc class i, immunogloburin domain, immune response, immune system, tcr, t cell receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P05534; Secreted . Note=(Microbial infection) In the presence of M: P61769; Host cell membrane ; Lipid-anchor ; Cytoplasmic side : Q9Q5D4
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44684.70

構造登録者

Shimizu, A.,Fukai, S.,Yamagata, A.,Iwamoto, A.,Han, C. (登録日: 2013-11-08, 公開日: 2014-06-11, 最終更新日: 2024-10-16)

主引用文献

Han, C.,Kawana-tachikawa, A.,Shimizu, A.,Zhu, D.,Nakamura, H.,Adachi, E.,Kikuchi, T.,Koga, M.,Koibuchi, T.,Gao, G.F.,Sato, Y.,Yamagata, A.,Martin, E.,Fukai, S.,Brumme, Z.L.,Iwamoto, A.
Switching and emergence of CTL epitopes in HIV-1 infection
Retrovirology, 11:38-38, 2014

PubMed Abstract: Human Leukocyte Antigen (HLA) class I restricted Cytotoxic T Lymphocytes (CTLs) exert substantial evolutionary pressure on HIV-1, as evidenced by the reproducible selection of HLA-restricted immune escape mutations in the viral genome. An escape mutation from tyrosine to phenylalanine at the 135th amino acid (Y135F) of the HIV-1 nef gene is frequently observed in patients with HLA-A*24:02, an HLA Class I allele expressed in ~70% of Japanese persons. The selection of CTL escape mutations could theoretically result in the de novo creation of novel epitopes, however, the extent to which such dynamic "CTL epitope switching" occurs in HIV-1 remains incompletely known.

PubMed: 24886641
DOI: 10.1186/1742-4690-11-38

実験手法

X-RAY DIFFRACTION (1.66 Å)