3WJN

Crystal structure of Octaprenyl Pyrophosphate synthase from Escherichia coli with farnesyl S-thiol-pyrophosphate (FSPP)

Summary for 3WJN

• Entry DOI: 10.2210/pdb3wjn/pdb
• Related: 3WJK 3WJO
• Descriptor: Octaprenyl diphosphate synthase, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE (3 entities in total)
• Functional Keywords: prenyltransferase, site-directed mutagenesis, product chain length, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 74337.77

Authors

Han, X.,Chen, C.C.,Kuo, C.J.,Huang, C.H.,Zheng, Y.,Ko, T.P.,Zhu, Z.,Feng, X.,Oldfield, E.,Liang, P.H.,Guo, R.T.,Ma, Y.H. (deposition date: 2013-10-12, release date: 2014-06-18, Last modification date: 2023-11-08)

• Primary citation: Han, X.,Chen, C.C.,Kuo, C.J.,Huang, C.H.,Zheng, Y.,Ko, T.P.,Zhu, Z.,Feng, X.,Wang, K.,Oldfield, E.,Wang, A.H.,Liang, P.H.,Guo, R.T.,Ma, Y.; Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.; Proteins, 83:37-45, 2015; PubMed: 24895191; DOI: 10.1002/prot.24618

Experimental method

X-RAY DIFFRACTION (2.6 Å)