3WAW

Crystal Structure of Autotaxin in Complex with 2BoA

3WAW の概要

• エントリーDOI: 10.2210/pdb3waw/pdb
• 関連するPDBエントリー: 3WAV 3WAX 3WAY
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 1,2-ETHANEDIOL, [2-({4-[(5Z)-5-(3,4-dichlorobenzylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperazin-1-yl}methyl)phenyl]boronic acid, ... (12 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 99813.90

構造登録者

Nishimasu, H.,Ishitani, R.,Nureki, O. (登録日: 2013-05-09, 公開日: 2013-07-31, 最終更新日: 2023-11-08)

• 主引用文献: Kawaguchi, M.,Okabe, T.,Okudaira, S.,Nishimasu, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T.; Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe; Acs Chem.Biol., 8:1713-1721, 2013; PubMed: 23688339; DOI: 10.1021/cb400150c

実験手法

X-RAY DIFFRACTION (1.954 Å)