3W9A

Crystal structure of the catalytic domain of the glycoside hydrolase family 131 protein from Coprinopsis cinerea

3W9A の概要

• エントリーDOI: 10.2210/pdb3w9a/pdb
• 分子名称: Putative uncharacterized protein, GLYCEROL (3 entities in total)
• 機能のキーワード: gh131, beta-jelly roll, hydrolase
• 由来する生物種: Coprinopsis cinerea (Inky cap fungus)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 112673.92

構造登録者

Miyazaki, T.,Tanaka, Y.,Tamura, M.,Yoshida, M.,Nishikawa, A.,Tonozuka, T. (登録日: 2013-04-01, 公開日: 2013-05-22, 最終更新日: 2024-10-30)

主引用文献

Miyazaki, T.,Yoshida, M.,Tamura, M.,Tanaka, Y.,Umezawa, K.,Nishikawa, A.,Tonozuka, T.
Crystal structure of the N-terminal domain of a glycoside hydrolase family 131 protein from Coprinopsis cinerea
Febs Lett., 587:2193-2198, 2013

PubMed Abstract: The crystal structure of the N-terminal putative catalytic domain of a glycoside hydrolase family 131 protein from Coprinopsis cinerea (CcGH131A) was determined. The structure of CcGH131A was found to be composed of a β-jelly roll fold and mainly consisted of two β-sheets, sheet-A and sheet-B. A concave of sheet-B, the possible active site, was wide and shallow, and three glycerol molecules were present in the concave. Arg96, Glu98, Glu138, and His218 are likely to be catalytically critical residues, and it was suggested that the catalytic mechanism of CcGH131A is different from that of typical glycosidases.

PubMed: 23711369
DOI: 10.1016/j.febslet.2013.05.041

実験手法

X-RAY DIFFRACTION (1.99 Å)