3W8O

Crystal Structure of HasAp with Iron Phthalocyanine

3W8O の概要

• エントリーDOI: 10.2210/pdb3w8o/pdb
• 関連するPDBエントリー: 3W8M 3WAH
• 分子名称: Heme acquisition protein HasAp, [29H,31H-phthalocyaninato(2-)-kappa~4~N~29~,N~30~,N~31~,N~32~]iron (3 entities in total)
• 機能のキーワード: heme binding protein, transport protein
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39228.06

構造登録者

Shirataki, C.,Shoji, O.,Terada, M.,Sugimoto, H.,Shiro, Y.,Watanabe, Y. (登録日: 2013-03-20, 公開日: 2014-01-29, 最終更新日: 2023-11-08)

主引用文献

Shirataki, C.,Shoji, O.,Terada, M.,Ozaki, S.,Sugimoto, H.,Shiro, Y.,Watanabe, Y.
Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp ) Bound to Synthetic Metal Complexes
Angew.Chem.Int.Ed.Engl., 53:2862-2866, 2014

PubMed Abstract: The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasA(p)) can capture several synthetic metal complexes other than heme. The crystal structures of HasA(p) harboring synthetic metal complexes revealed only small perturbation of the overall HasA(p) structure. An inhibitory effect upon heme acquisition by HasA(p) bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasA(p) bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasA(p) as an iron source.

PubMed: 24604808
DOI: 10.1002/anie.201307889

実験手法

X-RAY DIFFRACTION (1.85 Å)