3W0H

Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands

Summary for 3W0H

Entry DOI	10.2210/pdb3w0h/pdb
Related	3W0G 3W0I 3W0J
Descriptor	Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (2S)-3-{4-[4-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}phenyl)heptan-4-yl]phenoxy}propane-1,2-diol, ... (4 entities in total)
Functional Keywords	gene regulation, transcription
Biological source	Rattus norvegicus (rat) More
Cellular location	Nucleus: P13053 Q15648
Total number of polymer chains	2
Total formula weight	31325.09
Authors	Shimizu, T.,Asano, L.,Kuwabara, N.,Ito, I.,Waku, T.,Yanagisawa, J.,Miyachi, H. (deposition date: 2012-10-30, release date: 2013-10-09, Last modification date: 2023-11-08)
Primary citation	Asano, L.,Ito, I.,Kuwabara, N.,Waku, T.,Yanagisawa, J.,Miyachi, H.,Shimizu, T. Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands. Febs Lett., 587:957-963, 2013 Cited by PubMed: 23462137 DOI: 10.1016/j.febslet.2013.02.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation