3W09

Influenza virus neuraminidase subtype N9 (TERN) complexed with 2,3-dif guanidino-neu5ac2en inhibitor

3W09 の概要

• エントリーDOI: 10.2210/pdb3w09/pdb
• 関連するPDBエントリー: 1NNC 7NN9
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: neuraminidase, sialidase, hydrolase(o-glucosyl), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus
• 細胞内の位置: Virion membrane (By similarity): P03472
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46963.80

構造登録者

Streltsov, V.A. (登録日: 2012-10-25, 公開日: 2013-05-01, 最終更新日: 2023-11-08)

• 主引用文献: Kim, J.-H.,Resende, R.,Wennekes, T.,Chen, H.M.,Bance, N.,Buchini, S.,Watts, A.G.,Pilling, P.,Streltsov, V.A.,Petric, M.,Liggins, R.,Barrett, S.,McKimm-Breschkin, J.L.,Niikura, M.,Withers, S.G.; Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity; Science, 340:71-75, 2013; PubMed: 23429702; DOI: 10.1126/science.1232552

実験手法

X-RAY DIFFRACTION (2 Å)