3VRV
VDR ligand binding domain in complex with 2-Methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3
Summary for 3VRV
Entry DOI | 10.2210/pdb3vrv/pdb |
Related | 3VRT 3VRU 3VRW |
Descriptor | Vitamin D3 receptor, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-[(2R)-5-ethyl-5-hydroxyheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor, transcription, vitamin d3, vdre, rxr, co-factors, nuclear |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Nucleus: P13053 Q15648 |
Total number of polymer chains | 2 |
Total formula weight | 32596.60 |
Authors | Yoshimoto, N.,Inaba, Y.,Itoh, T.,Nakabayashi, M.,Ito, N.,Yamamoto, K. (deposition date: 2012-04-14, release date: 2012-05-23, Last modification date: 2024-03-20) |
Primary citation | Yoshimoto, N.,Sakamaki, Y.,Haeta, M.,Kato, A.,Inaba, Y.,Itoh, T.,Nakabayashi, M.,Ito, N.,Yamamoto, K. Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands J.Med.Chem., 55:4373-4381, 2012 Cited by PubMed: 22512505DOI: 10.1021/jm300230a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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