3VID
Crystal structure of human VEGFR2 kinase domain with Compound A.
Summary for 3VID
Entry DOI | 10.2210/pdb3vid/pdb |
Descriptor | Vascular endothelial growth factor receptor 2, 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole (3 entities in total) |
Functional Keywords | kinase, transferase, phosphorylation |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 40730.76 |
Authors | Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Hixon, M.S.,Kimura, H.,Miki, H. (deposition date: 2011-09-29, release date: 2012-08-15, Last modification date: 2024-03-20) |
Primary citation | Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Lawson, J.D.,Hixon, M.S.,Kimura, H.,Miki, H. A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3:342-346, 2012 Cited by PubMed: 24900475DOI: 10.1021/ml3000403 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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