3VB3

Crystal structure of SARS-CoV 3C-like protease in apo form

3VB3 の概要

• エントリーDOI: 10.2210/pdb3vb3/pdb
• 関連するPDBエントリー: 3VB4 3VB5 3VB6 3VB7
• 分子名称: 3C-like proteinase, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: SARS coronavirus (SARS-CoV)
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68293.87

構造登録者

Chuck, C.P.,Wong, K.B. (登録日: 2011-12-31, 公開日: 2012-12-12, 最終更新日: 2023-11-08)

• 主引用文献: Chuck, C.P.,Chen, C.,Ke, Z.,Wan, D.C.-C.,Chow, H.F.,Wong, K.B.; Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases; Eur.J.Med.Chem., 59C:1-6, 2012; PubMed: 23202846; DOI: 10.1016/j.ejmech.2012.10.053

実験手法

X-RAY DIFFRACTION (2.2 Å)