3VAD
Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid
Summary for 3VAD
Entry DOI | 10.2210/pdb3vad/pdb |
Descriptor | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Mitochondrion matrix: Q00972 |
Total number of polymer chains | 1 |
Total formula weight | 48393.06 |
Authors | Ahmed, K.,Gui, W.J.,Tso, S.C.,Chuang, J.L.,Wynn, R.M.,Chuang, D.T. (deposition date: 2011-12-29, release date: 2013-01-16, Last modification date: 2024-02-28) |
Primary citation | Ahmed, K.,Gui, W.J.,Tso, S.C.,Chuang, J.L.,M Wynn, R.,Chuang, D.T. Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid To be Published, |
Experimental method | X-RAY DIFFRACTION (2.602 Å) |
Structure validation
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