3VAD

Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid

Summary for 3VAD

• Entry DOI: 10.2210/pdb3vad/pdb
• Descriptor: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (rat)
• Cellular location: Mitochondrion matrix: Q00972
• Total number of polymer chains: 1
• Total formula weight: 48393.06

Authors

Ahmed, K.,Gui, W.J.,Tso, S.C.,Chuang, J.L.,Wynn, R.M.,Chuang, D.T. (deposition date: 2011-12-29, release date: 2013-01-16, Last modification date: 2024-02-28)

• Primary citation: Ahmed, K.,Gui, W.J.,Tso, S.C.,Chuang, J.L.,M Wynn, R.,Chuang, D.T.; Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid; To be Published,

Experimental method

X-RAY DIFFRACTION (2.602 Å)