3VAD

Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid

3VAD の概要

• エントリーDOI: 10.2210/pdb3vad/pdb
• 分子名称: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Mitochondrion matrix: Q00972
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48393.06

構造登録者

Ahmed, K.,Gui, W.J.,Tso, S.C.,Chuang, J.L.,Wynn, R.M.,Chuang, D.T. (登録日: 2011-12-29, 公開日: 2013-01-16, 最終更新日: 2024-02-28)

• 主引用文献: Ahmed, K.,Gui, W.J.,Tso, S.C.,Chuang, J.L.,M Wynn, R.,Chuang, D.T.; Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid; To be Published,

実験手法

X-RAY DIFFRACTION (2.602 Å)