3V66

HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid

Summary for 3V66

Entry DOI	10.2210/pdb3v66/pdb
Related	3ASX 3Q2Z 3Q30
Descriptor	Squalene synthase, PHOSPHATE ION, (1-{[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}piperidin-4-yl)acetic acid, ... (4 entities in total)
Functional Keywords	terpenoid synthase fold, isoprene biosynthesis, lipid synthesis, multifunctional enzyme, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
Total number of polymer chains	1
Total formula weight	39800.69
Authors	Suzuki, M.,Ohtsuka, M.,Ohki, H.,Haginoya, N.,Itoh, M.,Sugita, K.,Usui, H.,Ichikawa, M.,Higashihashi, N. (deposition date: 2011-12-18, release date: 2012-12-19, Last modification date: 2023-11-08)
Primary citation	Ichikawa, M.,Ohtsuka, M.,Ohki, H.,Haginoya, N.,Itoh, M.,Sugita, K.,Usui, H.,Suzuki, M.,Terayama, K.,Kanda, A. Discovery of novel tricyclic compounds as squalene synthase inhibitors Bioorg.Med.Chem., 20:3072-3093, 2012 Cited by PubMed: 22464687 DOI: 10.1016/j.bmc.2012.02.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation