3V4J

First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G

3V4J の概要

• エントリーDOI: 10.2210/pdb3v4j/pdb
• 分子名称: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION, 4-[methyl(nitroso)amino]benzene-1,2-diol, ... (4 entities in total)
• 機能のキーワード: hydrolase, apobec3g, antiviral defense, host-virus interaction, metal-binding, nucleus
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9HC16
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48774.05

構造登録者

Shandilya, S.M.D.,Ali, A.,Schiffer, C.A. (登録日: 2011-12-15, 公開日: 2012-02-01, 最終更新日: 2023-09-13)

• 主引用文献: Li, M.,Shandilya, S.M.,Carpenter, M.A.,Rathore, A.,Brown, W.L.,Perkins, A.L.,Harki, D.A.,Solberg, J.,Hook, D.J.,Pandey, K.K.,Parniak, M.A.,Johnson, J.R.,Krogan, N.J.,Somasundaran, M.,Ali, A.,Schiffer, C.A.,Harris, R.S.; First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G.; Acs Chem.Biol., 7:506-517, 2012; PubMed: 22181350; DOI: 10.1021/cb200440y

実験手法

X-RAY DIFFRACTION (2.04 Å)