3V35

Aldose reductase complexed with a nitro compound

3V35 の概要

• エントリーDOI: 10.2210/pdb3v35/pdb
• 関連するPDBエントリー: 3V36
• 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate, ... (5 entities in total)
• 機能のキーワード: aldose reductase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40801.54

構造登録者

Zheng, X.,Zhang, L.,Chen, Y.,Luo, H.,Hu, X. (登録日: 2011-12-13, 公開日: 2012-08-29, 最終更新日: 2023-11-08)

主引用文献

Zheng, X.,Zhang, L.,Chen, W.,Chen, Y.,Xie, W.,Hu, X.
Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7:1921-1923, 2012

PubMed Abstract: A little is more than enough: Aldose reductase (AR) is a potential target in a wide range of diseases but its utility may be limited by the side effects caused by complete inhibition. Furthermore, known inhibitors of AR have suffered in clinical evaluation due to poor bioavailability. Here, the clinically used antiprotozoal drug nitazoxanide with proven bioavailability has been shown to partially inhibit AR, potentially circumventing the negatives effects of complete enzyme inhibition.

PubMed: 22890894
DOI: 10.1002/cmdc.201200333

実験手法

X-RAY DIFFRACTION (1.9 Å)