3UYO

Crystal structure of monobody SH13/ABL1 SH2 domain complex

3UYO の概要

• エントリーDOI: 10.2210/pdb3uyo/pdb
• 関連するPDBエントリー: 3K2M 3NCS
• 分子名称: Tyrosine-protein kinase ABL1, Monobody SH13, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein-protein binding complex, signaling protein/protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23872.24

構造登録者

Wojcik, J.B.,Koide, A.,Koide, S. (登録日: 2011-12-06, 公開日: 2011-12-28, 最終更新日: 2023-09-13)

• 主引用文献: Koide, A.,Wojcik, J.,Gilbreth, R.N.,Hoey, R.J.,Koide, S.; Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold.; J.Mol.Biol., 415:393-405, 2012; PubMed: 22198408; DOI: 10.1016/j.jmb.2011.12.019

実験手法

X-RAY DIFFRACTION (1.83 Å)