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3UWO

Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation

Summary for 3UWO
Entry DOI10.2210/pdb3uwo/pdb
Related3UWK 3UXM
DescriptorThymidylate kinase, 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide (3 entities in total)
Functional Keywordsthymidylate kinase, kinase, thymidine triphosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourcePseudomonas aeruginosa
Total number of polymer chains2
Total formula weight48709.34
Authors
Choi, J.Y.,Plummer, M.S.,Starr, J.,Desbonnet, C.R.,Soutter, H.H.,Chang, J.,Miller, J.R.,Dillman, K.,Miller, A.A.,Roush, W.R. (deposition date: 2011-12-02, release date: 2012-02-01, Last modification date: 2024-02-28)
Primary citationChoi, J.Y.,Plummer, M.S.,Starr, J.,Desbonnet, C.R.,Soutter, H.,Chang, J.,Miller, J.R.,Dillman, K.,Miller, A.A.,Roush, W.R.
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.
J.Med.Chem., 55:852-870, 2012
Cited by
PubMed: 22243413
DOI: 10.1021/jm201349f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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