3UWK
Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation
Summary for 3UWK
Entry DOI | 10.2210/pdb3uwk/pdb |
Related | 3UWO 3UXM |
Descriptor | Thymidylate kinase, 1-methyl-6-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | thymidylate kinase, kinase, thymidine triphosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 51378.48 |
Authors | Choi, J.Y.,Plummer, M.S.,Starr, J.,Desbonnet, C.R.,Soutter, H.H.,Chang, J.,Miller, J.R.,Dillman, K.,Miller, A.A.,Roush, W.R. (deposition date: 2011-12-02, release date: 2012-02-01, Last modification date: 2024-02-28) |
Primary citation | Choi, J.Y.,Plummer, M.S.,Starr, J.,Desbonnet, C.R.,Soutter, H.,Chang, J.,Miller, J.R.,Dillman, K.,Miller, A.A.,Roush, W.R. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation. J.Med.Chem., 55:852-870, 2012 Cited by PubMed: 22243413DOI: 10.1021/jm201349f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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