3UWK

Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation

3UWK の概要

• エントリーDOI: 10.2210/pdb3uwk/pdb
• 関連するPDBエントリー: 3UWO 3UXM
• 分子名称: Thymidylate kinase, 1-methyl-6-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: thymidylate kinase, kinase, thymidine triphosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51378.48

構造登録者

Choi, J.Y.,Plummer, M.S.,Starr, J.,Desbonnet, C.R.,Soutter, H.H.,Chang, J.,Miller, J.R.,Dillman, K.,Miller, A.A.,Roush, W.R. (登録日: 2011-12-02, 公開日: 2012-02-01, 最終更新日: 2024-02-28)

• 主引用文献: Choi, J.Y.,Plummer, M.S.,Starr, J.,Desbonnet, C.R.,Soutter, H.,Chang, J.,Miller, J.R.,Dillman, K.,Miller, A.A.,Roush, W.R.; Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.; J.Med.Chem., 55:852-870, 2012; PubMed: 22243413; DOI: 10.1021/jm201349f

実験手法

X-RAY DIFFRACTION (1.91 Å)