3UOU

Crystal structure of the Kunitz-type protease inhibitor ShPI-1 Lys13Leu mutant in complex with pancreatic elastase

Summary for 3UOU

Entry DOI	10.2210/pdb3uou/pdb
Descriptor	Chymotrypsin-like elastase family member 1, Kunitz-type proteinase inhibitor SHPI-1, SULFATE ION, ... (5 entities in total)
Functional Keywords	protein-protein interaction, hydrolase (serine protease), kunitz-type inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Stichodactyla helianthus (Carribean sea anemone) More
Cellular location	Secreted: P00772 P31713
Total number of polymer chains	2
Total formula weight	33451.15
Authors	Garcia-Fernandez, R.,Perbandt, M.,Rehders, D.,Gonzalez-Gonzalez, Y.,Chavez, M.A.,Betzel, C.,Redecke, L. (deposition date: 2011-11-17, release date: 2012-11-21, Last modification date: 2023-09-13)
Primary citation	Garcia-Fernandez, R.,Perbandt, M.,Rehders, D.,Ziegelmuller, P.,Piganeau, N.,Hahn, U.,Betzel, C.,Chavez, M.A.,Redecke, L. Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme. J.Biol.Chem., 290:14154-14165, 2015 Cited by PubMed: 25878249 DOI: 10.1074/jbc.M115.647586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation