3ULG

Crystal structure of Calcium-Binding Protein-1 from Entamoeba histolytica in complex with barium

3ULG の概要

• エントリーDOI: 10.2210/pdb3ulg/pdb
• 分子名称: Calcium-binding protein, BARIUM ION (3 entities in total)
• 機能のキーワード: calcium-binding motif, metal binding protein
• 由来する生物種: Entamoeba histolytica
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30765.67

構造登録者

Kumar, S.,Gourinath, S. (登録日: 2011-11-10, 公開日: 2012-10-24, 最終更新日: 2023-11-01)

主引用文献

Kumar, S.,Ahmed, E.,Kumar, S.,Khan, R.H.,Gourinath, S.
Flexibility of EF-hand motifs: Structural and thermodynamic studies of Calcium Binding Protein- 1 from Entamoeba histolytica with Pb2+, Ba2+, and Sr2+
BMC Biophys, 5:15-15, 2012

PubMed Abstract: EF-hand proteins can be activated by the binding of various heavy metals other than calcium, and such complexes can disturb the calcium-signaling pathway and cause toxicity and disease causing state. So far, no comprehensive study has been done to understand different heavy metals binding to calcium signaling proteins.

PubMed: 22906057
DOI: 10.1186/2046-1682-5-15

実験手法

X-RAY DIFFRACTION (3.2 Å)