3UIX

Crystal structure of Pim1 kinase in complex with small molecule inhibitor

Summary for 3UIX

Entry DOI	10.2210/pdb3uix/pdb
Descriptor	Proto-oncogene serine/threonine-protein kinase pim-1, 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	pim-1, leukemia cell lethality, substrate-peptide-binding residue, fluorescent correlation spectroscopy, inhibitor complex, in silico screening, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34781.22
Authors	Parker, L.J. (deposition date: 2011-11-06, release date: 2012-04-11, Last modification date: 2023-11-01)
Primary citation	Tsuganezawa, K.,Watanabe, H.,Parker, L.,Yuki, H.,Taruya, S.,Nakagawa, Y.,Kamei, D.,Mori, M.,Ogawa, N.,Tomabechi, Y.,Handa, N.,Honma, T.,Yokoyama, S.,Kojima, H.,Okabe, T.,Nagano, T.,Tanaka, A. A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide. J.Mol.Biol., 417:240-252, 2012 Cited by PubMed: 22306408 DOI: 10.1016/j.jmb.2012.01.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation